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  • Recent progress in pharmaceutical excipients as P-glycoprotein . . .
    This review aims to review and assess the performance of pharmaceutical excipients as P-glycoprotein permeability inhibitors in improving oral drug bioavailability in drug formulations by evaluating meta data from P-glycoprotein efflux in permeability and pharmacokinetics studies
  • Application Notes and Protocols for Preclinical Formulation of P-gp . . .
    These application notes provide a comprehensive guide for the formulation and preclinical evaluation of "P-gp inhibitor 5" to support its development as a potential MDR reversal agent or a pharmacokinetic enhancer
  • Recent progress in pharmaceutical excipients as P-glycoprotein . . .
    This review aims to review and assess the performance of pharmaceutical excipients as P-glycoprotein permeability inhibitors in improving oral drug bioavailability in drug formulations by evaluating meta data from P-glycoprotein efflux in permeability and pharmacokinetics studies
  • Lipid-Based Oral Formulation Strategies for Enhancing Bioavailability . . .
    The aim of this chapter is to provide a comprehensive, mechanism-driven review of lipid-based formulation strategies for enhancing the oral bioavailability of AIs Rather than listing individual formulations, we categorize delivery systems by their molecular targets (e g , P-gp, CYP450 enzymes), pharmacokinetic behavior, and formulation class
  • NOVEL FORMULATION APPROCHES FOR OPTIMISING DRUG DELIVERY OF ANTICANCER . . .
    P-gp may be tackled by (i) development of novel agents that are non-P-gp substrates, (ii) administration of agents known as P-gp inhibitors that inhibit P-gp or (iii) designing formulations that allow the drug to bypass efflux pump transport The (ii) technique is most explored, resulting in the development of several generations of P-gp inhibitors over past two decades Unfortunately, the
  • A Systematic Review and Classification of the Effects of P . . . - Springer
    P-gp modulators were classified as potent, moderate, weak or non-interactors for P-gly-coprotein, with or without cytochrome P450 3A4 impact, on the basis of the area under the concentration–time curve ratio This classification was adapted from the Food and Drug Administration criteria for cytochrome interactions
  • Glucosamine activates intestinal P-glycoprotein inhibiting drug . . .
    Abstract P-glycoprotein (P-gp) is a crucial drug efflux transporter in the gastrointestinal tract, reducing drug uptake and expelling harmful xenobiotics to prevent pathological changes
  • Recent Advances In Oral Solid Dosage Form Formulation And Development
    The Unsung Heroes of Drug Delivery Excipients, often overlooked, play a critical role in the formulation and performance of solid dosage forms Recent advancements in excipient technology have led to the development of innovative excipients that enhance drug delivery, improve product stability, and enhance patient experience
  • P-glycoprotein Inhibition for Optimal Drug Delivery
    Moreover, it can make the sustained release dosage forms of the substrates completely ineffective by limiting their absorptions 9 Usually, an inhibitor of P-gp is coadministered with the drug to enhance drug absorption 30,31 Methods are being developed in preparing clinically useful oral formulations of drugs having poor oral absorption, which
  • Role of P-Gp in Treatment of Cancer - Scientific Research Publishing
    P-glycoprotein (P-gp), a member of the ATP-binding cassette (ABC) family of transporters, plays a crucial role in the development of multi-drug resistance (MDR) in cancer treatment P-gp actively pumps chemotherapeutic drugs out of cancer cells, reducing their intracellular concentrations and thereby diminishing their efficacy





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