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  • Thymic selection threshold defined by compartmentalization of . . . - Nature
    We show that, at the selection threshold, a small increase in ligand affinity for the T-cell antigen receptor leads to a marked change in the activation and subcellular localization of Ras and
  • ARTICLES - Nature
    We show that, at the selection threshold, a small increase in ligand affinity for the T-cell antigen receptor leads to a marked change in the activation and subcellular localization of Ras and
  • ERK and cell death: ERK location and T cell selection - FEBS Press
    One possi-ble explanation may be the location of the active form of these signaling molecules within a cell It was recently shown, that in thymocytes, positive and nega-tive selecting ligands induce the localization of the components of the Ras⁄ERK cascade and active ERK into distinct subcellular compartments (Figs 1 and 2) [16]
  • Thymocyte selection: From signaling to epigenetic regulation
    The strength of regulation is also critical in discrimination between positive and negative selection because thymocytes that express strongly self-reactive TCRs undergo negative selection (apoptosis) rather than cell survival according to the affinity model of thymocyte selection
  • A requirement for sustained ERK signaling during thymocyte positive . . .
    It is unknown how the contrasting events of positive and negative selection can lead to the distinct biological outcomes of life or death An increasing body of evidence suggests that the duration of extracellular signal-regulated kinase (ERK) signaling plays a role in thymocyte selection
  • Ras and extracellular signal-regulated kinase signaling in thymocytes . . .
    RasGEF expression is developmentally regulated in thymocytes Thymocyte negative selection requires either Sos1 or RasGRP1, but is ERK-independent Ras-dependent and Ras-independent pathways signal to ERK in peripheral T cells Bam32−PLC-γ1−PAK1 complexes activate ERK independently of LAT and Ras
  • NIH Public Access Alexandre K. Rouquette-Jazdanian, and Lawrence E . . .
    Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells Robert L Kortum, Alexandre K Rouquette-Jazdanian, and Lawrence E Samelson
  • Positive vs Negative Selection in T Cells: Shaping Immunity
    Explore how positive and negative selection in T cells shape immune responses, focusing on maturation, receptor affinity, and thymic cell roles
  • Kinetics of Negative and Positive Selection in the Thymus
    Recent experiments show that CD4 + 8 + thymocytes represent the critical stage in T cell development at which the specificity of randomly generated αβ T cell receptors is screened These cells are deleted when the receptor binds to the MHC molecule plus specific peptide presented by bone marrow derived cells but are rescued from cell death and induced to mature if the receptor binds to the





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