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  • History of polio vaccination - World Health Organization (WHO)
    Polio is a highly infectious disease, mostly affecting young children, that attacks the nervous system and can lead to spinal and respiratory paralysis, and in some cases death
  • Poliomyelitis - World Health Organization (WHO)
    WHO fact sheet on poliomyelitis, a highly infectious disease caused by a virus The fact sheet includes key facts, global caseload, Global Eradication Initiative, progress, WHO response
  • Poliomyelitis - World Health Organization (WHO)
    Inactivated polio vaccine (IPV) was developed in 1955 by Dr Jonas Salk Also called the Salk vaccine IPV consists of inactivated (killed) poliovirus strains of all three poliovirus types IPV is given by intramuscular or intradermal injection and needs to be administered by a trained health worker
  • FACT SHEET: VACCINE-DERIVED POLIOVIRUS
    VACCINE-DERIVED POLIOVIRUS Global efforts to immunise children with the oral polio vaccine (OPV) have reduced wild poliovirus cases by 99 9% since 1988 The vaccine is very safe and interrupts person-to-person spread of polio However, on rare occasions, in under-immunised populations, the live weakened virus originally contained in OPV can mutate into circulating vaccine-derived poliovirus
  • A Brief History of Vaccination
    From 1952–1955, the first effective polio vaccine is developed by Jonas Salk and trials begin Salk tests the vaccine on himself and his family the following year, and mass trials involving over 1 3 million children take place in 1954 By 1960, a second type of polio vaccine, developed by Albert Sabin, is approved for use
  • Poliomyelitis (Polio) - World Health Organization (WHO)
    Poliomyelitis (Polio) Polio can be prevented through immunization Polio vaccine, given multiple times, almost always protects a child for life The development of effective vaccines to prevent paralytic polio was one of the major medical breakthroughs of the 20th century There are six different vaccines to stop polio transmission:
  • Vaccines and immunization - World Health Organization (WHO)
    Vaccines reduce risks of getting a disease by working with your body’s natural defenses to build protection When you get a vaccine, your immune system responds We now have vaccines to prevent more than 30 life-threatening diseases and infections, helping people of all ages live longer, healthier lives
  • WHO prequalifies an additional novel oral polio vaccine, strengthening . . .
    The World Health Organization (WHO) has prequalified an additional novel oral polio vaccine type 2 (nOPV2), further strengthening the global supply of a vaccine at the heart of efforts to stop poliovirus type 2 outbreaks more sustainably and accelerate progress towards polio eradication
  • Safety profile of nOPV2 vaccine
    The first polio vaccine was developed by Jonas Salk, from formaldehyde-inactivated wild polio viruses Salk’s IPV was tested and proved highly efficacious against paralytic poliomyelitis in a large clinical trial conducted in US schoolchildren in 1954, which was rapidly followed by licensure of the product and implementation of mass
  • Microsoft Word - Polio_GRADEtable1_OPVEffec_2015. docx
    Incidence of paralytic polio decreased by 85%, although only 35% of children 12-‐13 months of age had received 3 doses of the vaccine Kim-‐ Farley J et al (1984) conducted a case control study during an outbreak in Taiwan involving 1031 cases of paralytic polio





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