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  • Rechallenge therapy versus tyrosine kinase inhibitor (TKI . . .
    Abstract Currently, the standard third-line treatment options for advanced metastatic colorectal cancer (mCRC) include regorafenib, fruquintinib, and trifluridine tipiracil (TAS-102), but these drugs have limited clinical efficacy This study aims to evaluate the efficacy and survival outcomes of tyrosine kinase inhibitor (TKI) versus chemotherapy rechallenge in third-line treatment for
  • Lost in translation: Revisiting the use of tyrosine kinase . . .
    Patients with advanced or metastatic colorectal cancer ( (m)CRC) have limited effective treatment options resulting in high mortality rates A better understanding of the molecular basis of this disease has led to growing interest in small molecule tyrosine kinase inhibitors (TKIs) for its treatment
  • High-dose short-term osimertinib treatment is effective in . . .
    Most tyrosine kinase inhibitors (TKIs) have failed in clinical trials for metastatic colorectal cancer (mCRC) To leverage the additional lower-affinity targets that most TKIs have, high-dose
  • Zanzalintinib Atezolizumab Improves CRC Survival, Expands TKI . . .
    New trial results reveal zanzalintinib and atezolizumab significantly enhance survival in metastatic colorectal cancer, marking a breakthrough in treatment options
  • Exploring research frontiers and emerging trends of tyrosine . . .
    Background Tyrosine kinase inhibitors (TKIs) are a class of molecular targeted drugs designed to selectively inhibit tyrosine kinase activity associated with oncogenic signaling pathways and drivers, and have emerged as key therapeutic agents for colorectal cancer (CRC) The purpose of this study is to explore the research status and development trend of TKIs in CRC treatment Methods The Web
  • Fruquintinib as new treatment option in metastatic colorectal . . .
    Introduction Available treatments for colorectal cancer are limited However, in the last few years several advances and new treatment options became available and expanded the continuum of care in metastatic colorectal cancer (mCRC)
  • Abstract 6002: Tyrosine kinase inhibitor (TKI) plus PD-1 . . .
    Tyrosine kinase inhibitor (TKI) plus PD-1 blockade in TKI-responsive MSS pMMR metastatic colorectal adenocarcinoma (mCRC): Results of a multicenter, phase II trial (TRAP) [abstract] In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL
  • BC Cancer Protocol Summary for the Treatment of Unresectable . . .
    BC Cancer Protocol Summary for the Treatment of Unresectable or Metastatic Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Colorectal Cancer using Ipilimumab and Nivolumab Protocol Code


















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