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  • Brexpiprazole - ALZFORUM
    Background Brexpiprazole is an orally available dopamine receptor D2 partial agonist, and an atypical antipsychotic This quinolinone derivative is a successor to aripiprazole (Abilify, Aripiprex), an approved, widely used drug that is also a dopamine D2 receptor partial agonist Brexpiprazole is approved in the United States for the treatment of schizophrenia, and as an add-on therapy for
  • Efficacy and Safety of Brexpiprazole for the Treatment of . . . - ALZFORUM
    Grossberg GT, Kohegyi E, Mergel V, Josiassen MK, Meulien D, Hobart M, Slomkowski M, Baker RA, McQuade RD, Cummings JL Efficacy and Safety of Brexpiprazole for the Treatment of Agitation in Alzheimer's Dementia: Two 12-Week, Randomized, Double-Blind, Placebo-Controlled Trials Am J Geriatr Psychiatry 2020 Apr;28 (4):383-400 Epub 2019 Oct 1 PubMed
  • Brexpiprazole Eases Agitation in People with AD; So Does Being in a . . .
    Curiously, the benefit of brexpiprazole over placebo paled in comparison to the effect of merely participating in the trial, as agitation eased substantially in both the treatment and placebo groups This finding jibes with results of another agitation trial presented at the conference, which tested the anti-depressant mirtazapine in people with AD Though that drug worked no better than
  • Does Tau Mess With Oligodendrocyte Gene Methylation?
    More than 5,000 DNA methylation signals flare up in AD brain Nearly all associated with levels of soluble and phospho-tau A subset mucked up expression of oligodendrocyte genes, especially those involved in myelination
  • Aβ Assault on Neurons Targets ER, Calcium - ALZFORUM
    When it works properly, the endoplasmic reticulum (ER) constantly pumps out newly synthesized membrane proteins, perfectly folded and sorted to their proper cellular destination At the same time, this organelle keeps cellular calcium levels in balance But when the ER gets overloaded and stressed
  • Madrid: ICAD Conference Draws to a Close | ALZFORUM
    The 10th International Conference on Alzheimer’s Disease and Related Disorders, ICAD for short, ended yesterday just outside the palatial capital of Spain The conference attracted not only a record number of attendees—just above 5,000 from 50 countries—but also a visit by Queen Sofia, whose
  • hBACE | ALZFORUM
    In order to determine the impact of BACE overexpression on Aβ deposition, hBACE mice have been crossed with APP overexpressing mice, such as the Tg2576 model overexpressing APP with the Swedish mutation (Hsiao et al , 1996) BACE expression was comparable in the single BACE transgenic and the bigenic APPxBACE mice At 14–16 months, APPxBACE-H and APPxBACE-M mice had decreased cortical
  • Research Brief: SIRTs Keep Brain Minty Fresh | ALZFORUM
    The sirtuin protein SIRT1 is emerging as an important player in learning and memory, and may have potential as a therapeutic target in Alzheimer disease Fresh on the heels of a July 11 Nature paper that demonstrated a crucial role for SIRT1 in memory (see ARF related news story on Gao et al , 2010


















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