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  • PubMed
    PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books Citations may include links to full text content from PubMed Central and publisher web sites
  • FLT3 is associated with dendritic cell infiltration, tertiary lymphoid . . .
    We found that FLT3 alteration and expression were both significantly upregulated in AML and were associated with poor prognosis, which is opposite to its role in solid cancers The genes co-expressed with FLT3 in solid cancers were correlated with the regulation of the immune microenvironment
  • Targeting FMS-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia . . .
    • FLT3 mutations drive AML progression via uncontrolled proliferation and survival • Second-generation FLT3 inhibitors offer targeted, potent, and selective AML treatment • Drug resistance necessitates novel therapies combining inhibitors and personalized care
  • FLT3 is associated with dendritic cell infiltration, tertiary . . . - Nature
    We found that FLT3 alteration and expression were both significantly upregulated in AML and were associated with poor prognosis, which is opposite to its role in solid cancers The genes
  • Developments and challenges of FLT3 inhibitors in acute myeloid . . .
    FLT3 mutations are one of the most common genetic alterations in acute myeloid leukemia (AML) and are identified in approximately one-third of newly diagnosed patients Aberrant FLT3 receptor signaling has important implications for the biology and clinical management of AML
  • Deciphering the immuno-pathological role of FLT, and evaluation of a . . .
    In the present study, we leveraged bulk and single-cell RNA sequencing datasets from AML patients to determine the clinical significance of Fms-related receptor tyrosine kinase 3 (FLT3) alterations on the T-cell phenotype and immune response of AML patients
  • Checking your browser - reCAPTCHA - PubMed
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  • Targeting FLT3 for treating diseases: FLT3 inhibitors
    In this review, we highlight recent progress in the development of FLT3 inhibitors, provide an in-depth discussion of current issues associated with these inhibitors, and put forward suggestions to overcome such issues, with the aim of furthering development of novel FLT3 inhibitors
  • Impact of FLT3 mutation on its intracellular localization and . . .
    Recent studies have indicated that FLT3 mutated receptor has different intracellular localization of the protein, which can be specifically targeted This review summarizes the different intracellular localization of FLT3 protein, and the influence of different positions on downstream signals





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