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  • Cyclophilin A: a key player for human disease | Cell Death . . . - Nature
    Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin family
  • Peptidylprolyl isomerase A - Wikipedia
    Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by the PPIA gene on chromosome 7 [4][5][6] As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to
  • Cyclophilin A (CypA) | MedChemExpress
    Cyclophilin A (CypA), a key member of the immunophilin family, is the most abundantly expressed isozyme of the 18 known human cyclophilins
  • Progress of CypA and Lung Cancer-related Research - PMC
    CypA plays the roles in increasing proliferation, antiapoptosis, invasion and metastasis in lung cancer The study of CypA may open a new window for the early diagnosis, prognosis and novel therapeutic drugs targeting
  • Extracellular and Intracellular Cyclophilin A, Native and Post . . .
    In this review, we will discuss the shared and unique pathological roles of extracellular and intracellular CypA in human cardiovascular diseases In addition, the evolving role of post-translational modifications of CypA in the pathogenesis of disease is discussed
  • The effects of CypA on apoptosis: potential target for the . . . - Springer
    In this review, we focus on the effects of CypA on apoptosis and the relationship between specific mechanisms of CypA promoting or inhibiting apoptosis and diseases, including tumorigenesis, cardiovascular diseases, organ injury, and microbial infections
  • Full article: Cyclophilin A: promising target in cancer therapy
    Consequently, CypA can be further investigated as a useful tool for early diagnosis, treatment and prevention of human cancers This review mainly focuses on the critical role of CypA in cancer development and the therapeutic potential of targeted it in various cancer types Figure 1
  • Frontiers | Cyclophilin inhibition as a strategy for the treatment of . . .
    In the current model for the role of CypA in HIV-1 infection, cytosolic CypA present in infected cells binds directly to a proline-rich domain of the HIV-1 capsid that forms the shell (or core) that surrounds and protects the viral genome during its nuclear transport
  • Cyclophilin A - an overview | ScienceDirect Topics
    Cyclophilin A (CyPA) is defined as an abundantly expressed protein belonging to the immunophilin family, involved in various physiological and pathological activities, particularly in immune and infectious diseases, malignant tumors, and cardiovascular inflammation How useful is this definition?
  • What are CYPA inhibitors and how do they work?
    Cyclophilin A (CYPA) inhibitors are a fascinating and evolving area of pharmacological research Cyclophilin A is a protein that belongs to the family of immunophilins and exhibits peptidyl-prolyl isomerase activity, which is crucial in protein folding and trafficking
  • Cyclophilin A is overexpressed in human pancreatic cancer cells and . . .
    Although overexpression of cyclophilin A (CypA) is associated with several types of cancer, its role in pancreatic cancer has not been studied In this study the expression of CypA and its receptor CD147 on pancreatic cancer was determined as well as the effect of exogenous CypA on pancreatic cancer cell proliferation





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