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  • Galectin Therapeutics
    Galectin Therapeutics develops novel therapies to improve the lives of patients with chronic liver disease and cancer Galectin’s lead drug, belapectin (GR‑MD‑02), is a carbohydrate-based drug that inhibits the galectin‑3 protein, involved in many inflammatory, fibrotic, and malignant diseases
  • Galectin - Wikipedia
    Galectins are a class of proteins that bind specifically to β-galactoside sugars, such as N -acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding
  • The role of galectins in immunity and infection - Nature
    The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by a wide variety of cells and bind to galactose-containing glycans Galectins can be located in the
  • Galectin-3: Disarming Cancer’s Bodyguard - Dr. Axe
    Luckily, a large and fast-growing body of research has given us a specific therapeutic target to achieve this goal: the biological protein galectin-3
  • What is Galectin-3? High and low values | Lab results explained
    Galectin-3 is a carbohydrate-binding lectin whose expression is associated with inflammatory cells including macrophages, neutrophils, and mast cells – Concentrations of galectin-3 have been used to predict adverse remodeling after a variety of cardiac insults
  • What are galectin-3 inhibitors and how do they work?
    As a member of the galectin family, galectin-3 is a beta-galactoside-binding protein involved in numerous cellular processes, including cell growth, apoptosis, and immune responses
  • Galectin-3 induces neurodevelopmental apical-basal polarity and . . . - AAAS
    Galectin-3 (Gal-3) has been previously implicated in ABP of epithelial cells, and, here, we find that it is apically expressed in human embryonic stem cells (hESCs) during neural induction Gal-3 blockade disrupts ABP and alters the distribution of junctional proteins in hESC-derived neural rosettes and is rescued by addition of recombinant Gal-3
  • Galectins: An Amazing Marker and a Potential Therapeutic Target
    Galectins (Gal) are a wide group of proteins expressed in various cells, and they are particularly known for their ability to recognize and bind carbohydrates We present current evidence showing that Gal play roles in both acute and chronic inflammation pathways





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